[The cAMP system in the cerebral cortex of irradiated rats in increased exogenous K+ levels]

Treatment of grey matter of irradiated (0.21 Cl/kg) rats by 60 mM of KCl causing depolarization of cell membranes leads to the increase of the cAMP content and to the decrease of adenylatecyclase activity. Dynamics of the enzyme activity with an increase of the external KCl concentration in control is to a considerable extent similar to that after irradiation, though the latter is more pronounced and a time shift is observed for maximal increase of a cAMP content and cAMP phosphodiesterase activity.