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Fibroblast Growth Factor 2 and Its Receptors in Bone Biology and Disease

J Douglas Coffin1, Collin Homer-Bouthiette2, Marja Marie Hurley3

  • 1The University of Montana, Missoula, Montana.

Journal of the Endocrine Society
|June 27, 2018
PubMed

Insights

Fibroblast growth factor (FGF) signaling is crucial for bone and cartilage development. Complexities in FGF pathways present challenges for treating bone disorders like osteoporosis.

Area of Science:

  • Biochemistry and Molecular Biology
  • Developmental Biology
  • Endocrinology

Background:

  • The fibroblast growth factor (FGF) regulatory axis is an ancient signaling system.
  • It involves 22 ligands binding to four receptor tyrosine kinases in mammals.
  • FGFs primarily regulate cartilage and bone morphogenesis, mineralization, and metabolism.

Purpose of the Study:

  • To explore the complexities of FGF ligand-receptor signaling pathways.
  • To understand the challenges in developing therapies for FGF-related bone disorders.

Main Methods:

  • Review of existing literature on FGF signaling.
  • Analysis of FGF ligand-receptor interactions.
  • Examination of FGF's role in bone and cartilage physiology.

Main Results:

  • The FGF system is highly complex, involving numerous ligands and receptors.
  • FGF signaling is essential for skeletal development and homeostasis.
  • Therapeutic translation for bone disorders is hindered by pathway complexity.

Conclusions:

  • Despite challenges, targeting FGF pathways offers potential for treating bone disorders.
  • Further research into FGF signaling mechanisms is needed for therapeutic advancements.
  • Fibroblast growth factor signaling is critical for skeletal health and disease.
Keywords:
FGF receptorsFGF2bone

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