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Related Experiment Video

Updated: Feb 8, 2026

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Continuous Single-Step Wet Granulation with Integrated in-Barrel-Drying.

Adrian Schmidt1,2, Hans de Waard2, Peter Kleinebudde1

  • 1Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, 40225, Duesseldorf, Germany.

Pharmaceutical Research
|June 27, 2018
PubMed
Summary
This summary is machine-generated.

Continuous wet granulation and drying were successfully combined in a single twin-screw granulator step, known as in-barrel-drying. This innovative process yields dried granules, potentially eliminating the need for separate drying equipment.

Keywords:
API suspension feeddesign of experimentsfluidised-bed dryingtelescoped processtwin-screw wet granulation

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Area of Science:

  • Pharmaceutical Engineering
  • Process Intensification

Background:

  • Traditional pharmaceutical manufacturing involves separate wet granulation and drying steps.
  • Fluidized-bed drying is a common but energy-intensive downstream process.

Purpose of the Study:

  • To investigate the feasibility of combining continuous wet granulation and drying in a single twin-screw granulator.
  • To achieve (pre-)dried granules in a one-step, in-barrel-drying process.

Main Methods:

  • Utilized a two-compartment twin-screw granulator with differential temperature control.
  • Employed Design of Experiments to optimize the in-barrel-drying process.
  • Compared the process with traditional fluidized-bed drying, evaluating granule and compact properties.

Main Results:

  • Demonstrated the feasibility of in-barrel-drying, producing completely dried and granulated material.
  • Identified evaporation zone temperature and processed water mass as critical parameters.
  • Achieved acceptable product quality for granules and compacts.

Conclusions:

  • In-barrel-drying effectively condenses granulation and drying into a single piece of equipment.
  • This integrated approach can significantly reduce or eliminate downstream drying steps.
  • Offers a more efficient and potentially cost-effective manufacturing solution.