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Published on: March 27, 2018
Postoperative complications after elective coronary artery bypass grafting surgery in patients with sleep-disordered
Maria Tafelmeier1, Teresa Weizenegger2, Sarah Ripfel2
1Department of Internal Medicine II (Cardiology, Pneumology, and Intensive Care), University Medical Centre Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany. maria.tafelmeier@ukr.de.
Insights
Sleep-disordered breathing (SDB), especially obstructive sleep apnea (OSA), significantly prolongs hospital stays after coronary artery bypass grafting (CABG). This increased length of stay is linked to greater postoperative hemodynamic instability.
Area of Science:
- Cardiology
- Sleep Medicine
- Anesthesiology
Background:
- Sleep-disordered breathing (SDB) is a potential risk factor for complications following cardiac surgery.
- Understanding the impact of SDB subtypes, central sleep apnea (CSA) and obstructive sleep apnea (OSA), on postoperative outcomes is crucial.
Purpose of the Study:
- To evaluate the association between SDB and length of hospital stay (LOS) after elective coronary artery bypass grafting (CABG).
- To assess the impact of SDB on postoperative cardiac, respiratory, and renal complications.
- To determine if SDB influences postoperative hemodynamic instability.
Main Methods:
- Polygraphic recordings assessed SDB presence and type (CSA, OSA) in 100 patients pre-CABG.
- SDB defined by apnea-hypopnea index (AHI) ≥ 15/h.
- Retrospective analysis of prolonged LOS, hemodynamic instability, and other complications.
Main Results:
- 37% of patients had SDB (14% CSA, 23% OSA).
- Patients with OSA had significantly longer LOS compared to those without SDB (p=0.005).
- Higher AHI correlated with prolonged LOS (OR 1.047, p=0.044) and need for vasopressors (OR 1.052, p=0.040).
Conclusions:
- Obstructive sleep apnea (OSA) is independently associated with prolonged LOS post-CABG.
- Increased postoperative hemodynamic instability may contribute to longer hospital stays in SDB patients.
- SDB management should be considered in cardiac surgery patients to optimize recovery.
Background:
Sleep-disordered breathing (SDB) may increase the risk of postoperative complications in patients after cardiac surgery. This study evaluated the length of hospital stay as well as postoperative cardiac, respiratory, and renal complications after elective coronary artery bypass grafting (CABG) in patients without SDB, with central sleep apnea (CSA), or with obstructive sleep apnea (OSA).
Methods:
The presence and type of SDB had been assessed with polygraphic recordings in 100 patients the night before elective CABG surgery. SDB was defined as an apnea-hypopnea index (AHI) of ≥ 15/h. Prolonged length of hospital stay (LOS) and postoperative hemodynamic instability due to any cause were retrospectively evaluated as primary endpoints and cardiac, respiratory, and renal complications as secondary endpoints.
Results:
37% of patients had SDB, 14% CSA, and 23% OSA. LOS differed significantly between patients without SDB and those with CSA and OSA [median (25;75. percentile): 8.0 days (7.5;11.0) vs. 9.5 days (7.0;12.5) vs. 12.0 days (9.0;17.0), Kruskal-Wallis test between three groups: p = 0.023; OSA vs. no SDB: p = 0.005]. AHI was significantly associated with prolonged LOS [> 9 days; odds ratio (OR) (95% confidence interval): 1.047 (1.001;1.095), p = 0.044]. Prolonged need of vasopressors (≥ 48 h) was observed in 36% of patients without SDB, in 64% with CSA, and in 62% with OSA (p = 0.037). AHI was significantly associated with prolonged (≥ 48 h) need of vasopressors [OR (95% CI): 1.052 (1.002;1.104), p = 0.040], independent of any confounders.
Conclusions:
SDB, particularly OSA, is associated with prolonged LOS after CABG, independent of known confounders. Prolonged LOS in patients with SDB may be due to increased postoperative hemodynamic instability due to any cause.
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