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Anlotinib: First Global Approval

Yahiya Y Syed1

  • 1Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand. dru@adis.com.

Drugs
|June 27, 2018
PubMed

Insights

Anlotinib, an oral tyrosine kinase inhibitor, is now approved in China for advanced non-small cell lung cancer (NSCLC) patients who progressed after chemotherapy. This marks a significant milestone for this targeted cancer therapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Development

Background:

  • Anlotinib is an oral small molecule inhibitor targeting multiple receptor tyrosine kinases.
  • It exhibits broad-spectrum inhibition of tumor angiogenesis and growth.
  • Jiangsu Chia-Tai Tianqing Pharmaceutical and Advenchen Laboratories are co-developing anlotinib.

Purpose of the Study:

  • To summarize the development milestones of anlotinib.
  • To highlight the drug's first approval for non-small cell lung cancer (NSCLC).

Main Methods:

  • Review of anlotinib's development pathway.
  • Summary of clinical development stages and regulatory approvals.

Main Results:

  • Anlotinib is approved in China for advanced or metastatic NSCLC post-chemotherapy.
  • Phase II and III clinical development is ongoing for various sarcomas and carcinomas in China, USA, and Italy.

Conclusions:

  • Anlotinib's approval for NSCLC represents a key achievement in its development.
  • The drug shows potential for treating various advanced cancers.

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