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Updated: Feb 8, 2026

The Encapsulation of Cell-free Transcription and Translation Machinery in Vesicles for the Construction of Cellular Mimics
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Published on: October 21, 2013

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A new baby in the c-Myc-directed transcriptional machinery: Che-1/AATF

Valentina Folgiero1, Cristina Sorino2, Franco Locatelli1,3

  • 1a Department of Pediatric Hematology/Oncology and of Cell and Gene Therapy , Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.

Cell Cycle (Georgetown, Tex.)
|June 27, 2018
PubMed

Insights

High expression of Che-1/AATF and c-Myc in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) drives cancer cell proliferation. Silencing Che-1/AATF enhances chemotherapy response, identifying it as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pediatric Hematology

Background:

  • B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood cancer.
  • While cure rates are high, novel therapeutic targets are needed.
  • High expression of c-Myc and Che-1/AATF is observed in pediatric BCP-ALL.

Purpose of the Study:

  • To investigate the role of c-Myc and Che-1/AATF co-expression in pediatric BCP-ALL.
  • To explore Che-1/AATF as a potential therapeutic target in BCP-ALL.

Main Methods:

  • Analysis of c-Myc and Che-1/AATF expression in pediatric BCP-ALL patient samples.
  • Investigating the molecular mechanisms of c-Myc and Che-1/AATF co-expression.
  • Assessing the effect of Che-1/AATF silencing on BCP-ALL cell proliferation and chemotherapy response.

Main Results:

  • Che-1/AATF expression is crucial for c-Myc-driven blast-cell proliferation in BCP-ALL.
  • High expression of c-Myc and Che-1/AATF diminishes upon remission.
  • Silencing Che-1/AATF in primary BCP-ALL cells enhances sensitivity to chemotherapy.

Conclusions:

  • Che-1/AATF plays a critical role in c-Myc-driven tumorigenicity in BCP-ALL.
  • Che-1/AATF represents a promising novel therapeutic target for BCP-ALL treatment.
  • Targeting Che-1/AATF may improve treatment outcomes for pediatric BCP-ALL patients.

Keywords:
BCP-ALLChe-1c-Myc

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