Related Experiment Video
Updated: Feb 8, 2026
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
Recent Advances and Developments of in vitro Evaluation of Heterocyclic Moieties on Cancer Cell Lines
Runjhun Tandon1, Iqubal Singh2, Vijay Luxami2
1Department of Chemistry, School of Physical Sciences, Lovely Professional University, Phagwara-, 144411, India.
Abstract:
Besides worthy development in cancer therapy, cancer is still one of the leading causes of death, worldwide. The future burden of cancer will probably be even larger because people are adopting poor lifestyles with poor diet, frequently smoking and less physical activity. The effective anticancer drugs having efficacy and selectivity with low toxicity is still a challenge for the scientific fraternity. The advances in the cancer study have its origin on the availability of different types of experimental model systems that review the various forms of this disease. Cell lines emerge as a feasible alternative for anticancer activities, being at the same time easy to manipulate and molecularly characterize. Heterocycles are key structural components of many of the anti-cancer drugs available on the market today. Indeed, of the novel molecular anti-cancer agents approved by the FDA between 2010 and 2017, almost two-thirds contained heterocyclic rings within their structures. This review summarizes and provides updated literature on heterocyclic compounds using various cancer cell lines reported during the period of 2014-2017 together with the structure-activity relationships.
Insights
Heterocyclic compounds show promise as effective anticancer drugs, with many FDA-approved agents featuring these structures. This review details their efficacy against various cancer cell lines from 2014-2017.
Area of Science:
- Medicinal Chemistry
- Oncology
- Drug Discovery
Background:
- Cancer remains a leading global cause of death, with increasing incidence linked to lifestyle factors.
- Developing effective anticancer drugs with high efficacy, selectivity, and low toxicity is a significant challenge.
- Experimental model systems, particularly cell lines, are crucial for advancing cancer research and drug development.
Purpose of the Study:
- To review and update literature on the anticancer activities of heterocyclic compounds.
- To focus on studies utilizing various cancer cell lines reported between 2014 and 2017.
- To analyze structure-activity relationships of promising heterocyclic anticancer agents.
Main Methods:
- Literature search of scientific databases for relevant studies published from 2014-2017.
- Inclusion of studies reporting anticancer activity of heterocyclic compounds against cancer cell lines.
- Analysis of reported structure-activity relationships.
Main Results:
- Heterocyclic compounds are integral to many modern anticancer drugs.
- A significant proportion of novel anticancer agents approved by the FDA (2010-2017) contain heterocyclic rings.
- The review synthesizes data on the efficacy of diverse heterocyclic compounds against various cancer cell lines.
Conclusions:
- Heterocyclic compounds represent a vital class of molecules in the development of novel anticancer therapeutics.
- Further research into structure-activity relationships can guide the design of more potent and selective anticancer agents.
- Cell line models are instrumental in evaluating the potential of new heterocyclic anticancer drug candidates.
Related Concept Videos
01:16Cell Lines
01:25Basicity of Heterocyclic Aromatic Amines
01:10Nomenclature of Aryl and Heterocyclic Amines
01:13Five-Membered Heterocyclic Aromatic Compounds: Overview
01:23Lossless Lines
02:22Overview of Advanced Functional Groups
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.