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Comparative effectiveness from a single-arm trial and real-world data: alectinib versus ceritinib
Jessica Davies1, Michael Martinec2, Paul Delmar2
1Roche Products Ltd, 6 Flacon Way, Shire Park, Welwyn Garden City, AL7 1TW, UK.
Alectinib significantly improved overall survival in anaplastic lymphoma kinase-positive non-small-cell lung cancer patients compared to ceritinib. This finding supports alectinib as a superior treatment option for this patient group.
Area of Science:
- Oncology
- Pharmacology
Background:
- Anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer (NSCLC) is a distinct subtype.
- Targeted therapies have improved outcomes for ALK+ NSCLC patients.
Purpose of the Study:
- To compare the overall survival (OS) of ALK+ NSCLC patients treated with alectinib versus ceritinib.
Main Methods:
- Retrospective analysis of two treatment arms (alectinib n=183; ceritinib n=67) from clinical trials and an electronic health record database.
- Propensity score adjustment was used to balance baseline characteristics.
- Kaplan-Meier analysis and multivariate Cox regression were performed to assess OS.
Main Results:
- After propensity score adjustment, baseline characteristics were balanced between groups.
- Alectinib demonstrated a prolonged median OS (24.3 months) compared to ceritinib (15.6 months).
- Alectinib was associated with a significantly lower risk of death (hazard ratio: 0.65; 95% CI: 0.48-0.88).
Conclusions:
- Alectinib is associated with prolonged overall survival in ALK+ NSCLC patients compared to ceritinib.
- These findings align with existing clinical trial data, reinforcing alectinib's efficacy.
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