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Comparative effectiveness from a single-arm trial and real-world data: alectinib versus ceritinib
Jessica Davies1, Michael Martinec2, Paul Delmar2
1Roche Products Ltd, 6 Flacon Way, Shire Park, Welwyn Garden City, AL7 1TW, UK.
Aim:
To compare the overall survival of anaplastic lymphoma kinase-positive non-small-cell lung cancer patients who received alectinib with those who received ceritinib.
Materials & Methods:
Two treatment arms (alectinib [n = 183] and ceritinib [n = 67]) were extracted from clinical trials and an electronic health record database, respectively. Propensity scores were applied to balance baseline characteristics. Kaplan-Meier and multivariate Cox regression were conducted.
Results:
After propensity score adjustment, baseline characteristics were balanced. Alectinib had a prolonged median overall survival (alectinib = 24.3 months and ceritinib = 15.6 months) and lower risk of death (hazard ratio: 0.65; 95% CI: 0.48-0.88).
Conclusion:
Alectinib was associated with prolonged overall survival versus ceritinib, which is consistent with efficacy evidence from clinical trials.
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