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Polymorphism related to cardiovascular risk in hemodialysis subjects: a systematic review

Karla Pereira Balbino1, Helen Hermana Miranda Hermsdorff1, Josefina Bressan1

  • 1Universidade Federal de Viçosa, Departamento de Nutrição e Saúde, Viçosa, MG, Brasil.

Jornal Brasileiro De Nefrologia
|June 27, 2018
PubMed

Insights

Genetic factors, specifically single nucleotide polymorphisms (SNPs), significantly impact cardiovascular disease (CVD) risk in hemodialysis (HD) patients. Understanding these genetic links is crucial for managing CVD in this vulnerable population.

Area of Science:

  • Nephrology
  • Genetics
  • Cardiology

Background:

  • Cardiovascular disease (CVD) is a primary cause of death in hemodialysis (HD) patients.
  • Traditional risk factors are prevalent, but genetic factors, particularly single nucleotide polymorphisms (SNPs), also play a role.

Purpose of the Study:

  • To systematically review studies investigating polymorphisms associated with cardiovascular risk in hemodialysis subjects.
  • To identify specific genetic variations influencing CVD in this population.

Main Methods:

  • Systematic literature review of studies on genetic polymorphisms and cardiovascular risk in HD patients.
  • Analysis of identified SNPs and their associated genes.

Main Results:

  • SNPs in genes related to inflammation, oxidative stress, and vascular calcification are common in HD individuals.
  • These genetic variations can influence cardiovascular risk.
  • Polymorphisms in genes linked to dyslipidemia, hypertension, and left ventricular hypertrophy also affect CVD outcomes.

Conclusions:

  • Genetic polymorphisms are significant contributors to cardiovascular morbidity and mortality in hemodialysis patients.
  • Targeting these genetic factors may offer new avenues for CVD risk management in HD populations.

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