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Published on: September 11, 2018
Izenamides A and B, Statine-Containing Depsipeptides, and an Analogue from a Marine Cyanobacterium
Yuki Kanamori1, Arihiro Iwasaki1, Shimpei Sumimoto1
1Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi , Ko-hoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
Abstract:
Izenamides A, B, and C (1-3), new linear depsipeptides, were isolated from a taxonomically distinct marine cyanobacterium. Izenamides A and B contain a statine moiety [(3 S,4 S)-4-amino-3-hydroxy-6-methylheptanoic acid] and inhibited the activity of cathepsin D, an aspartic peptidase. Meanwhile, izenamides did not show growth-inhibitory activity against HeLa, HL60, or MCF-7 cells at up to 10 μM.
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