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Related Experiment Videos

Parenteral premedication with lorazepam--a dose/response study.

C O Odugbesan, J A Magbagbeola

    African Journal of Medicine and Medical Sciences
    |March 1, 1985
    PubMed
    Summary

    Parenteral lorazepam effectively provides sedation and amnesia before anesthesia. Intravenous administration offers faster onset and is recommended at 2 mg, with minimal cardiovascular and respiratory effects.

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    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Preoperative medication is crucial for patient comfort and procedural success.
    • Lorazepam is a commonly used anxiolytic and sedative agent.

    Purpose of the Study:

    • To evaluate the dose-response relationship of parenteral lorazepam as a premedicant.
    • To compare intramuscular versus intravenous administration routes.
    • To assess sedative, amnesic, cardiovascular, and respiratory effects.

    Main Methods:

    • Comparative study of intramuscular and intravenous lorazepam administration.
    • Doses studied: 2 mg, 3 mg, and 4 mg.
    • Evaluation of sedation, amnesia, blood pressure, pulse rate, and respiratory function.

    Main Results:

    • Intravenous lorazepam demonstrated more pronounced sedative and amnesic effects compared to intramuscular.
    • Sedation and amnesia were dose-dependent for both administration routes.
    • Minimal impact on cardiovascular parameters and respiratory function was observed.
    • Lorazepam 2 mg intravenously was as effective as higher doses, with reduced nausea and vomiting.

    Conclusions:

    • Intravenous lorazepam is a suitable premedicant, offering rapid sedation onset.
    • The 2 mg intravenous dose is recommended for efficacy and tolerability.
    • Close patient monitoring is essential with intravenous administration.

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