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Antifungal photodynamic inactivation against dermatophyte Trichophyton rubrum using nanoparticle-based hybrid

Niranga Wijesiri1, Zhao Yu1, Hong Tang1

  • 1Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, United States.

Photodiagnosis and Photodynamic Therapy
|June 27, 2018
PubMed

Insights

This study explores a novel antifungal photodynamic therapy for Trichophyton rubrum (T. rubrum) infections. Using nanoparticle-based photosensitizers, researchers achieved significant fungal killing without antifungal drugs, showing potential for treating nail and ringworm infections.

Area of Science:

  • Biomedical Engineering
  • Photochemistry
  • Mycology

Background:

  • Trichophyton rubrum (T. rubrum) is a prevalent dermatophyte causing widespread fungal nail and ringworm infections globally.
  • Current treatments for T. rubrum infections can be limited by drug resistance and side effects.

Purpose of the Study:

  • To investigate the efficacy of mesoporous silica-coated silver nanoparticle-based hybrid photosensitizers for antifungal photodynamic inactivation of T. rubrum.
  • To evaluate the potential of this approach as a drug-free therapeutic strategy.

Main Methods:

  • Utilized mesoporous silica-coated silver nanoparticle-based hybrid photosensitizers.
  • Applied photodynamic inactivation to T. rubrum (ATCC 28188) cultures.
  • Assessed cytotoxicity of the hybrid photosensitizers under experimental conditions.

Main Results:

  • Achieved significant fungal killing of T. rubrum, approximately 3 orders of magnitude.
  • Demonstrated low cytotoxicity of the hybrid photosensitizers at effective concentrations.
  • Successfully inactivated T. rubrum without the use of conventional antifungal drugs.

Conclusions:

  • Nanoparticle-based hybrid photosensitizers show promise for antifungal photodynamic therapy.
  • This drug-free approach offers a potential new strategy for managing T. rubrum infections.
  • Further research is warranted to explore clinical applications of this photodynamic therapy.
Keywords:
Antifungal photodynamic inactivationHybrid photosensitizerMesoporous silica nanoparticlesSinglet oxygenTrichophyton rubrum

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