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Techniques to Induce and Quantify Cellular Senescence
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Techniques to Induce and Quantify Cellular Senescence

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Combating cellular senescence by sirtuins: Implications for atherosclerosis

Sai Ma1, Li Fan2, Feng Cao3

  • 1Department of Cardiology, National Clinical Research Center of Geriatric Disease, Chinese PLA General Hospital, Beijing, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|June 27, 2018
PubMed

Insights

Cellular senescence contributes to atherosclerosis, a key factor in cardiovascular diseases. Activating sirtuins, known for anti-aging properties, may offer a new therapeutic strategy against this condition.

Area of Science:

  • Biomedical Science
  • Cardiovascular Research
  • Cellular Biology

Background:

  • Cellular senescence, a state of permanent cell cycle arrest, is increasingly recognized as a significant factor in the development of atherosclerosis.
  • Atherosclerosis is a primary pathological process underlying cardiovascular diseases (CVDs).

Purpose of the Study:

  • To review current research on the role of sirtuins in regulating cellular senescence within the context of atherosclerosis.
  • To explore the potential of sirtuin activation as a therapeutic approach for managing atherosclerosis.

Main Methods:

  • Literature review of recent findings on sirtuins and cellular senescence in atherosclerosis.
  • Analysis of the physiological functions of sirtuins, including their role in cellular metabolism and aging.

Main Results:

  • Sirtuins, a class of cellular deacetylases, possess anti-aging properties and influence various physiological activities.
  • Evidence suggests sirtuins play a role in modulating cellular senescence, a process implicated in atherosclerosis.

Conclusions:

  • Sirtuins demonstrate potential beneficial effects in combating atherosclerosis by influencing cellular senescence.
  • Targeting sirtuin activation presents a promising therapeutic avenue for cardiovascular disease prevention and treatment.
Keywords:
AtherosclerosisCellular senescenceSirtuins

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