Biocompatible gadolinium oxide nanoparticles as efficient agent against pathogenic bacteria.

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Growing antibiotic resistance necessitates novel antimicrobial agents.
• Metal nanoparticles offer potential antibacterial properties.
• Gadolinium oxide nanoparticles are being explored for biomedical applications.

Purpose of the Study:

• To synthesize and characterize l-ascorbic acid coated gadolinium oxide nanoparticles.
• To evaluate the safety and antimicrobial efficacy of these nanoparticles.
• To assess their potential for biomedical applications.

Main Methods:

• Precipitation synthesis of l-ascorbic acid coated gadolinium oxide nanoparticles.
• Characterization using FT-IR, TEM, and FE-SEM.
• Cytotoxicity assessment on HaCaT cells and antimicrobial testing against E. coli, S. aureus, and S. typhimurium.

Main Results:

• Successful synthesis of spherical gadolinium oxide nanoparticles coated with l-ascorbic acid confirmed by FT-IR.
• Nanoparticles exhibited good chemical and colloidal stability.
• Non-toxic to HaCaT cells up to 125 µg/mL.
• Demonstrated antimicrobial activity against tested bacterial strains.

Conclusions:

• l-Ascorbic acid coated gadolinium oxide nanoparticles are synthesized successfully.
• The nanoparticles are non-toxic and exhibit antimicrobial properties.
• These nanoparticles hold potential for future biomedical applications in combating bacterial infections.