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Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
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Logarithmic functions are powerful tools for simplifying the mathematical representation of phenomena involving exponential changes. Their ability to convert multiplicative relationships into additive ones is especially valuable in various scientific and engineering contexts. One notable application of logarithms is measuring sound intensity, specifically through the decibel (dB) scale used in acoustics.Sound intensity levels vary over an extensive range, from the faintest audible whisper to...
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Consider a structure made of a boom and a rod designed to support a load. These two components are connected by a pin and stabilized by brackets and pins. The boom and the rod are detached from their supports to assess the different stresses imposed on this structure, and a free-body diagram is drawn. Then, all the forces applied, including the load acting on the structure, are identified. The reaction forces exerted on both the boom and the rod are computed using the equilibrium equations.
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Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
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N-halamine-based multilayers on titanium substrates for antibacterial application.

Bailong Tao1, Xinkun Shen1, Zhang Yuan1

  • 1Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China.

Colloids and Surfaces. B, Biointerfaces
|June 27, 2018
PubMed
Summary
This summary is machine-generated.

This study developed an antibacterial coating for titanium orthopedic implants using chitosan-1-(hydroxymethyl)-5,5-dimethylhydantoin and gelatin. The novel coating effectively inhibited bacterial growth without harming bone cells, offering a promising solution for implant infections.

Keywords:
Antimicrobial coatingCytocompatibilityLayer-by-layer assemblyN-halamineTitanium substrates

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Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Infectious Diseases

Background:

  • Bacterial infections are a major cause of orthopedic implant failure.
  • Titanium (Ti) implants are susceptible to bacterial colonization.
  • Developing effective antibacterial strategies for Ti substrates is crucial.

Purpose of the Study:

  • To create a bioactive coating for titanium (Ti) substrates to enhance antibacterial properties.
  • To investigate the efficacy of a chitosan-1-(hydroxymethyl)-5,5-dimethylhydantoin (Chi-HDH-Cl) and gelatin (Gel) coating against bacterial adhesion and growth.
  • To assess the biocompatibility of the modified Ti substrates with osteoblasts.

Main Methods:

  • Fabrication of a Gel/Chi-HDH-Cl coating on Ti substrates using layer-by-layer (LBL) assembly.
  • Characterization of the coating using Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (1HNMR), and X-ray photoelectron spectroscopy (XPS).
  • Evaluation of surface morphology, roughness, and wettability using scanning electron microscopy (SEM), atomic force microscopy (AFM), and water contact angle measurements.
  • In vitro antibacterial assays against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).
  • In vitro cytotoxicity tests on osteoblasts.

Main Results:

  • Successful synthesis of the Chi-HDH-Cl conjugate confirmed by spectroscopic methods.
  • Formation of multilayers on Ti substrates demonstrated by SEM, AFM, and contact angle measurements.
  • Significantly inhibited adhesion and growth of E. coli and S. aureus on Gel/Chi-HDH-Cl modified Ti substrates.
  • Gel/Chi-HDH-Cl multilayers exhibited no obvious cytotoxicity to osteoblasts.

Conclusions:

  • The LBL assembly technique effectively produced an antibacterial Gel/Chi-HDH-Cl coating on Ti substrates.
  • The developed coating demonstrates potent antibacterial activity against common orthopedic pathogens.
  • The biocompatibility of the coating suggests its potential for orthopedic applications, reducing implant-associated infections.