Related Experiment Video

Updated: Feb 8, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.3K

Long Non-Coding RNA in Glioma: Target miRNA and Signaling Pathways

Yuan Dang, Xudong Wei, Laien Xue

    Clinical Laboratory
    |June 27, 2018
    PubMed
    Abstract

    Insights

    Long noncoding RNAs (lncRNAs) are key players in glioma development and progression. Targeting lncRNAs offers a promising therapeutic strategy for treating this aggressive central nervous system cancer.

    Area of Science:

    • Neuro-oncology
    • Molecular Biology
    • RNA Therapeutics

    Background:

    • Glioma represents a significant challenge as a common and aggressive central nervous system malignancy.
    • Understanding the molecular underpinnings of glioma is crucial for developing effective treatments.

    Purpose of the Study:

    • To review and explore the potential of long noncoding RNAs (lncRNAs) as a therapeutic strategy for glioma.
    • To investigate the role of lncRNAs in glioma pathogenesis and progression.

    Main Methods:

    • Literature review and analysis of existing research on lncRNAs in glioma.
    • Exploration of lncRNA involvement in key signaling pathways implicated in glioma.

    Main Results:

    • lncRNAs are non-protein-coding functional RNA molecules implicated in glioma occurrence and progression.
    • lncRNAs regulate critical signaling pathways such as MAPK, p53, Wnt/β-catenin, PI3K/AKT/mTOR, and EMT in gliomas.
    • Interactions between lncRNAs and microRNAs (miRNAs) influence glioma growth and progression.

    Conclusions:

    • lncRNA participation in signaling pathway regulation is vital for glioma development.
    • Determining lncRNA-miRNA interactions can pave the way for novel and effective glioma therapies.

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