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Updated: Feb 8, 2026

Visualization of Cortical Modules in Flattened Mammalian Cortices
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Marchiafava-Bignami Disease with Cortical Involvement.

Panpan Zhao, Hongliang Zhang, Ying Zhang

    Clinical Laboratory
    |June 27, 2018
    PubMed
    Summary

    Marchiafava-Bignami disease (MBD) in a chronic alcoholic showed corpus callosum and cortical lesions. Advanced MRI techniques like DTI and MRS helped assess prognosis, revealing impaired myelin and axonal integrity.

    Area of Science:

    • Neurology
    • Neuroimaging
    • Degenerative Disorders

    Background:

    • Marchiafava-Bignami disease (MBD) is a rare neurological disorder characterized by demyelination of the corpus callosum.
    • It predominantly affects chronic alcoholics and can present with cortical lesions, indicating a poorer prognosis.
    • This case involves a chronic alcoholic presenting with confusion and generalized weakness.

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