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Updated: Feb 8, 2026

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
The neuropathic pain component among patients with chronic low back-radicular pain
Objectives:
Determining neuropathic pain component (NPC) among patients with chronic low back pain-radicular pain (CLBP-RP) and the adjustment between scales of neuropathic pain.
Material-Methods:
One hundred and one patients with CLBP-RP were included in the study. The severity of CLBP-RP was evaluated by visual analogue scale (VAS). The Douleur Neuropathique 4 Questions (DN4) and Leeds Assessment of Neuropathic Symptoms and Signs Scales (LANSS) were used to evaluate the NPC.
Results:
The mean score of CLBP-RP assessed by VAS was 80 mm. NPC was detected a rate of 65.3% by DN4 and 40.6% by LANSS. NPC was 75.4% in females and 47.2% in males according to DN4, and 52.3% in females and 19.4% in males according to LANSS. The female gender, occupation, and VAS scores were determined to be significant factors contributing to presence of NPC according to logistic regression analyses (p< 0.01, p< 0.05, p< 0.05). A medium degree accordance was established between DN4 and LANSS scales according to kappa coefficient (Kappa = 0.532, p< 0.05).
Conclusion:
CLBP is among the diseases causing mixed type pain accompanied by nociceptive and neuropathic pain. NPC was detected in a considerable part of patients with radicular pain. Identifying the character of radicular pain is significant to develop proper management strategies.
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