Related Experiment Video

Updated: Feb 8, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

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Identification of serum miR-34a as a potential biomarker in acute myeloid leukemia

Yiqun Huang, Yong Zou, Luhui Lin

    Cancer Biomarkers : Section a of Disease Markers
    |June 28, 2018
    PubMed
    Abstract

    Insights

    MicroRNA-34a (miR-34a) is downregulated in acute myeloid leukemia (AML) and can serve as a diagnostic and prognostic biomarker. Lower miR-34a levels correlate with poorer outcomes in AML patients.

    Area of Science:

    • Hematology
    • Molecular Biology
    • Oncology

    Background:

    • MicroRNA-34a (miR-34a) is a known tumor suppressor inducing apoptosis in acute myeloid leukemia (AML).
    • The diagnostic and prognostic value of miR-34a in AML is not well-established.
    • Investigating miR-34a's role can uncover potential biomarkers for AML diagnosis and prognosis.

    Purpose of the Study:

    • To investigate the association of serum miR-34a levels with clinical characteristics in AML patients.
    • To evaluate the diagnostic and prognostic significance of miR-34a in AML.
    • To analyze miR-34a expression in cytogenetically-normal AML (CN-AML) for biomarker potential.

    Main Methods:

    • Serum miR-34a levels were quantified using qRT-PCR in 117 AML patients and 60 controls.
    • miR-34a expression was further analyzed in 56 CN-AML subjects.
    • Correlations with clinical features, patient outcomes, and diagnostic accuracy (ROC analysis) were assessed.

    Main Results:

    • miR-34a was significantly downregulated in AML and CN-AML patients compared to controls.
    • Underexpression of miR-34a was linked to intermediate/poor risk cytogenetics and the M5 subtype.
    • Serum miR-34a demonstrated diagnostic potential and served as an independent prognostic indicator, with lower levels associated with shorter survival.

    Conclusions:

    • miR-34a exhibits potential as a diagnostic biomarker for distinguishing AML patients from healthy individuals.
    • miR-34a serves as a valuable prognostic indicator in AML, correlating with patient survival and disease recurrence.
    • The findings suggest miR-34a could be a significant clinical tool for AML management.
    Keywords:
    acute myeloid leukemiabiomarkerdiagnosismiR-34aprognosis

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