Related Experiment Video
Updated: Feb 8, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
Published on: September 8, 2017
Real world evidence: Abiraterone use post-docetaxel in metastatic castrate-resistant prostate cancer
Alisha Shivji1, Raafi Ali2, Scott North2
11 Tom Baker Cancer Center, Calgary, Canada.
Objectives:
The COU-AA-301 trial demonstrated that in men with metastatic castrate-resistant prostate cancer using abiraterone post-docetaxel increased overall survival. This study aims to assess this conclusion in a real world context.
Design:
Retrospective chart review of a provincial Pharmacy BDM Database (a pharmacy dispensing software) and a provincial Electronic Chart (ARIA). Dispensing data, information on the state of the disease before and after abiraterone use, and information regarding effects of abiraterone were gathered.
Setting:
Cancer centers in Alberta, Canada.
Patients:
Metastatic castrate-resistant prostate cancer (CRPC) patients on abiraterone outside of a clinical trial who have previously had docetaxel chemotherapy for CRPC between February 2012 and May 2014.
Primary Outcome:
Overall survival from the time of abiraterone initiation.
Results:
Overall survival increase of 17 months was consistent with the survival increase of 14.8 months observed in the pivotal trial.
Conclusion:
Abiraterone is a valuable therapy post-docetaxel for metastatic CRPC, as in a real world context it demonstrated an increase in overall survival that was consistent with the findings of the clinical trial despite including a patient population of older age and lower performance status.
Related Concept Videos
The Evidence for Evolution
Treatment Resistant Cancers
Resistivity
Resistance
Equivalent Resistance
Resistance and Conductance
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...

