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Current scenario of plasmid-mediated colistin resistance in Latin America

Cecilia Quiroga1, Marcela Nastro2, José Di Conza3

  • 1Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Tecnológicas, Instituto de Investigaciones en Microbiología y Parasitología Médica (IMPAM), Facultad de Medicina, Paraguay 2155, C1121ABG, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290 (1425), Ciudad Autónoma de Buenos Aires, Argentina.

Revista Argentina De Microbiologia
|June 28, 2018
PubMed

Insights

The emergence of mcr-1, a colistin resistance gene, is a growing concern in Latin America. This review examines mcr-1 positive Enterobacteriaceae strains and their spread, highlighting associated resistance markers.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Colistin resistance is a significant global health threat.
  • Resistance mechanisms include chromosomal mutations and plasmid-mediated genes, notably mcr-1.
  • The rapid spread of mcr-1 has raised alarms in the healthcare community.

Purpose of the Study:

  • To review documented cases of mcr-1 positive Enterobacteriaceae in Latin America.
  • To analyze the association of mcr-1 with other resistance markers, such as ESBL.
  • To identify the dissemination platforms of the mcr-1 gene.

Main Methods:

  • Systematic review of published reports and available data.
  • Compilation of information on mcr-1 positive Enterobacteriaceae strains.
  • Analysis of co-occurrence with Extended-Spectrum Beta-Lactamase (ESBL) resistance markers.

Main Results:

  • Documented presence of mcr-1 positive Enterobacteriaceae strains in Argentina and other Latin American countries.
  • Frequent co-occurrence of mcr-1 with ESBL resistance genes.
  • Identification of various mobile genetic elements and platforms facilitating mcr-1 dissemination.

Conclusions:

  • The mcr-1 gene is actively disseminating in Latin America.
  • Co-resistance with ESBL markers is common, complicating treatment options.
  • Understanding dissemination platforms is crucial for controlling the spread of colistin resistance.
Keywords:
América LatinaColistin resistanceEnterobacteriaceaeLatin AmericaResistencia a colistinamcr-1

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