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Paternity testing by using erythrocyte enzyme esterase D.

D D Dykes, H F Polesky

    Journal of Forensic Sciences
    |January 1, 1977
    PubMed
    Summary

    Esterase D (EsD) testing in 206 paternity cases identified 5 exonerations among 39 exclusions. This enzyme system proves to be a reliable and easy-to-use genetic marker for paternity testing exclusions.

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    Area of Science:

    • Forensic Genetics
    • Biochemistry
    • Paternity Testing

    Background:

    • Paternity testing relies on genetic markers to establish biological relationships.
    • Exclusionary power of genetic systems is crucial for accurate forensic casework.
    • Esterase D (EsD) is an erythrocyte enzyme with known genetic variations.

    Purpose of the Study:

    • To evaluate the utility of the esterase D (EsD) enzyme system as a genetic marker in paternity testing.
    • To assess the exclusionary power of EsD in conjunction with existing genetic marker systems.
    • To determine the reliability and ease of use of EsD testing for forensic applications.

    Main Methods:

    • Phenotyping of 206 individuals involved in paternity disputes using 15 routine genetic marker systems.
    • Inclusion of esterase D (EsD) enzyme phenotyping in the genetic analysis.
    • Analysis of results to identify exclusions and assess the contribution of EsD to exonerations.

    Main Results:

    • A total of 39 exclusions were observed across the 206 paternity cases analyzed.
    • The esterase D (EsD) enzyme system was responsible for exonerating 5 falsely accused males.
    • EsD testing demonstrated high reliability and was straightforward to perform.

    Conclusions:

    • Esterase D (EsD) is a valuable genetic marker for enhancing the accuracy of paternity testing.
    • The enzyme's reliability and ease of testing make it a practical tool for forensic exclusion.
    • EsD contributes significantly to the exclusionary power of combined genetic analyses in paternity cases.

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