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Updated: Feb 8, 2026

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Published on: August 8, 2025
Utility of Prolotherapy for Upper Extremity Pathology
Shashank Dwivedi1, Andrew D Sobel1, Manuel F DaSilva1
1Department of Orthopaedic Surgery, Warren Alpert School of Medicine, Brown University, Providence, RI.
Abstract:
Prolotherapy is a method of treatment of painful musculoskeletal conditions whereby a sclerosing agent is injected into an area of tendinosis or osteoarthritis to strengthen and repair painful connective tissue. It is a safe, effective, and relatively inexpensive nonsurgical treatment modality. This article provides a history of prolotherapy, discusses its proposed mechanisms of action, and provides a review of the existing literature on prolotherapy as a treatment for upper extremity pathologies, specifically, hand osteoarthritis, lateral epicondylitis, and rotator cuff disease.
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