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Related Experiment Video

Updated: Feb 8, 2026

Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain

Time-lapse Live Imaging of Clonally Related Neural Progenitor Cells in the Developing Zebrafish Forebrain

Published on: April 6, 2011

What does time mean in development?

Miki Ebisuya¹, James Briscoe²

¹RIKEN Center for Biosystems Dynamics Research (RIKEN BDR), 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, 650-0047, Japan miki.ebisuya@riken.jp james.briscoe@crick.ac.uk.

Development (Cambridge, England)

|June 28, 2018

Summary

This summary is machine-generated.

Developmental biology explores the critical role of timing in embryonic development. Understanding the coordination of cellular events and species-specific tempos is key to deciphering developmental processes.

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Area of Science:

Developmental Biology
Cellular Dynamics
Evolutionary Biology

Background:

Biological processes occur across vast timescales, from sub-second molecular events to millions of years of evolution.
Developmental processes like cell division, differentiation, gene expression, cell-cell signaling, and morphogenesis occur at intermediate timescales.
The regulation of tempo and order in developmental events remains a key question.

Purpose of the Study:

To discuss the significance of time in embryonic development.
To highlight the need for both global and cell-autonomous control mechanisms.
To explore how the sequence and coordination of developmental events are managed.

Main Methods:

Review of existing literature on developmental timing.
Discussion of new reagents and tools for imaging and genomic engineering.
Consideration of in vitro culture techniques.

Main Results:

Emphasizes the necessity of precise temporal control in embryonic development.
Suggests that both organism-wide (global) and individual cell (cell-autonomous) mechanisms regulate developmental timing.
Highlights emerging technologies that provide new molecular insights.

Conclusions:

Temporal dynamics are fundamental to understanding biological processes, especially embryonic development.
Advanced imaging, genetic engineering, and in vitro methods are crucial for investigating the origins and mechanisms of developmental time.
Further research is needed to fully elucidate the coordination and control of developmental sequences across species.