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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Assembly of Signaling Complexes01:30

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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
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Yeast Signaling01:28

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Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Complexes with Interchangeable Parts01:57

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Related Experiment Video

Updated: Feb 8, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Wnt signalling: conquering complexity.

Katrin E Wiese1, Roel Nusse2, Renée van Amerongen3

  • 1Section of Molecular Cytology and Van Leeuwenhoek Centre for Advanced Microscopy, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands.

Development (Cambridge, England)
|June 28, 2018
PubMed
Summary
This summary is machine-generated.

The Wnt signaling pathway

Keywords:
CancerModel organismsStem cellsWnt signalling

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Area of Science:

  • Developmental biology
  • Molecular signaling
  • Genetics

Background:

  • The Wnt pathway is crucial for development and disease.
  • Its history spans across various model organisms.
  • Developmental biology has been key to understanding Wnt signaling.

Purpose of the Study:

  • To trace the historical contributions of developmental biology to Wnt pathway research.
  • To illustrate how different scientific disciplines elucidated Wnt pathway mechanisms.
  • To highlight the Wnt pathway's role in stem cell biology and tissue growth.

Main Methods:

  • Review of developmental genetics studies.
  • Analysis of research in model organisms (mice, flies, frogs, zebrafish).
  • Examination of stem cell fate and tissue growth analyses.

Main Results:

  • Identification of key molecular players in Wnt signaling.
  • Elucidation of biochemical functions and cell biological activities.
  • Demonstration of Wnt pathway's conserved role in development and disease.

Conclusions:

  • Developmental biology has been instrumental in understanding the Wnt pathway.
  • The Wnt pathway is a conserved signaling process vital for development and implicated in disease.
  • Ongoing research into Wnt signaling offers potential for new clinical applications.