Is There a Role for Thiopurines in IBD?

Immunosuppressive therapy (IM) is inexpensive and nearly one-third of patients with inflammatory bowel disease (IBD) experience a benefit from treatment. IM may be ideal for IBD patients at low risk for a disabling disease course or colectomy and/or those patients with inadequate access to biologic therapy. A majority of IBD patients benefit from early biologic therapy with improved short and likely long-term outcomes. Improved methods are needed to identify patients at the greatest risk for a severe disease course and that are likely to respond to the various forms of small molecule and biologic treatments. Health systems need to identify innovative methods to contain costs of biologic therapy.