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Updated: Feb 8, 2026

Author Spotlight: Investigating the Mechanism of Action of Acupotomy in Treating Knee Osteoarthritis
Published on: October 20, 2023
Association of TNF-α-308 G > A and -238G > A polymorphisms with knee osteoarthritis risk: A case-control study and
Mohammad Reza Sobhan1, Masoud Mahdinezhad-Yazdi2, Kazem Aghili3
1Department of Orthopedics, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Objective:
A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA).
Methods:
Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified.
Results:
Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk. Similarly, in the stratified analysis by ethnicity, no significant association was found.
Conclusion:
This meta-analysis results inconsistent with the previous meta-analyses showed that the TNF-α -308 G > A and -238G > A polymorphisms may not be associated with the susceptibility to knee OA.
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