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Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

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Disruption of Boundary Encoding During Sensorimotor Sequence Learning: An MEG Study.

Georgios Michail^1,2, Vadim V Nikulin^1,3,4, Gabriel Curio¹

¹Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Frontiers in Human Neuroscience

|June 28, 2018

Summary

This summary is machine-generated.

Learning sequences, like in music, involves encoding order. This study shows that altering auditory feedback at sequence boundaries, compared to within-sequence elements, causes more errors and distinct neural activity in prefrontal and motor areas.

Keywords:

boundaries prefrontal cortex sensorimotor learning sequence learning serial order supplementary motor area

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Area of Science:

Neuroscience
Cognitive Science
Auditory-Motor Learning

Background:

Sensorimotor sequence learning is crucial for skills like music performance.
Encoding the serial order of actions and sounds is key to this learning process.
Boundary elements (first/last) in sequences have shown specific neural representations in prior animal and patient studies.

Purpose of the Study:

To investigate how altered auditory feedback (AF) at different sequence positions affects neural and behavioral responses during sensorimotor learning in humans.
To explore the neural mechanisms underlying the encoding of sequence boundaries in healthy individuals.
To differentiate the neural processing of boundary elements versus within-sequence elements.

Main Methods:

Magnetoencephalography (MEG) was used to record neural activity from 20 participants.
Participants learned and performed short piano sequences with occasional altered auditory feedback (AF).
Behavioral data on performance errors and reaction times were collected alongside neural data.

Main Results:

Neural activity in the dorsolateral prefrontal cortex (DLPFC) and supplementary motor area (SMA) showed distinct patterns for boundary versus within-sequence elements around 150-200 ms post-keystroke.
Altered auditory feedback at sequence boundaries resulted in significantly greater performance costs, including increased errors in subsequent actions.
These findings indicate a dissociation in neural processing based on the ordinal position of elements within a learned sequence.

Conclusions:

The proper encoding of sequence boundaries is critical for successful sensorimotor sequence acquisition.
Distinct neural circuitry, involving prefrontal and higher-order motor areas, is engaged in encoding different classes of serial order elements in humans.
This study provides novel insights into the human neural mechanisms differentiating the processing of sequence beginnings/ends from intermediate elements.