Related Experiment Video
Updated: Feb 8, 2026
Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
Published on: April 19, 2024
A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control
Xianglin Yang1,2, Xuelian Li2,3, Baosen Zhou1,2
1Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang, China.
Abstract:
MicroRNAs (miRNAs) are a class of endogenous, short and non-coding RNAs that may play important roles in the pathogenesis of tumor. The associations between microRNA-499 rs3746444 polymorphism and cancer risk in different systems remain inconclusive. This article is aimed to obtain more exact estimation of these relationships through a meta-analysis based on 52,456 individuals. We retrieved relevant and eligible studies from Pubmed and Embase database up to January 10, 2018. ORs and 95% CIs were used to estimate the associations between miR-499 polymorphism and cancer susceptibility in different systems. All analyses were performed using the Stata 11.0 software. A total of 65 case-control studies were retrieved using explicit inclusion and exclusion criteria. The study included 23,762 cases and 28,694 controls. Overall cancer analysis showed the association between miR-499 polymorphism and susceptibility to cancer was significant. MicroRNA-499 rs3746444 was found to be significantly associated with increased risk of cancer of the respiratory system (CC vs. TT: OR = 1.575, 95% CI = 1.268-1.955, CC vs. TC+TT: OR = 1.527, 95% CI = 1.232-1.892), digestive system (CC vs. TT: OR = 1.153, 95% CI = 1.027-1.295; TC vs. TT: OR = 1.109, 95% CI = 1.046-1.176; CC+TC vs. TT: OR = 1.112, 95% CI = 1.018-1.216; CC vs. TC+TT: OR = 1.137, 95% CI = 1.016-1.272; C vs. T: OR = 1.112, 95% CI = 1.025-1.206), urinary system (TC vs. TT: OR = 1.307, 95% CI = 1.130-1.512; CC+TC vs. TT: OR = 1.259, 95% CI = 1.097-1.446; C vs. T: OR = 1.132, 95% CI = 1.014-1.264), and gynecological system (C vs. T: OR = 1.169, 95% CI = 1.002-1.364). In the subgroup analysis by ethnicity, the result showed that significant association with an increased cancer risk was found in Asian. Subgroup analysis based on type of tumor was also performed, miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma.
More Related Videos
06:26Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
04:34Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Related Concept Videos
01:10Control Systems
At the heart...
02:55The Evidence for Evolution
01:25Control Systems: Applications
In modern vehicles, control systems manage various functions to enhance performance and safety. The steering wheel and accelerator are primary inputs in a car's control system. The...
01:26Feedback control systems
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
01:17Open and closed-loop control systems
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
01:21Transfer Function in Control Systems
To derive the transfer function, consider a general nth-order linear time-invariant...