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Updated: Feb 8, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Chemerin is elevated in multiple myeloma patients and is expressed by stromal cells and pre-adipocytes
Marita Westhrin1,2, Siv Helen Moen1,2, Ida Bruun Kristensen3
11Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Abstract:
Chemerin is a recently discovered adipokine shown to be involved in both inflammatory and metabolic processes. Here, we demonstrate that chemerin serum levels are elevated in patients with multiple myeloma and that it increases with disease progression. We found that chemerin is expressed by stromal cells and preadipocytes, whereas its receptor CCRL2 is expressed by primary myeloma cells, suggesting a paracrine signaling loop between bone marrow stromal cells/adipocytes and myeloma cells. This is the first study exploring chemerin and its receptors in multiple myeloma.
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