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Related Concept Videos

Chronic Pharyngitis01:23

Chronic Pharyngitis

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Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Obstructive Pulmonary Disease01:24

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
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Related Experiment Video

Updated: Feb 8, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Unresponsive Intractable Chronic Headache With Sitagliptin.

Ahmed Zaghloul1, Corina Iorgoveanu1, Andrew Polio1

  • 1Internal Medicine, University of Connecticut Health Center, Farmington, USA.

Cureus
|June 28, 2018
PubMed
Summary
This summary is machine-generated.

Sitagliptin, a DPP-4 inhibitor for diabetes, is linked to potential adverse events. This case highlights a patient whose chronic headache resolved after discontinuing sitagliptin, emphasizing post-marketing surveillance.

Keywords:
diabetesheadachessitagliptin

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Area of Science:

  • Pharmacology
  • Endocrinology
  • Clinical Medicine

Background:

  • Sitagliptin is a widely prescribed dipeptidyl peptidase 4 (DPP4) inhibitor for type 2 diabetes management.
  • Commonly reported side effects include upper respiratory infections, nasopharyngitis, headache, and gastrointestinal upset.
  • Post-marketing surveillance has indicated potential associations with acute pancreatitis and joint pain.

Observation:

  • A case study involving a patient with type II diabetes and chronic headache is presented.
  • The patient was undergoing treatment with sitagliptin, a DPP4 inhibitor.
  • The chronic headache experienced by the patient showed rapid resolution upon discontinuation of sitagliptin.

Findings:

  • The resolution of chronic headache following sitagliptin cessation suggests a potential causal link.
  • This observation contrasts with the generally mild and common adverse events typically associated with sitagliptin.
  • The case underscores the importance of considering less common or long-term side effects of medications.

Implications:

  • Continuous monitoring and robust post-marketing surveillance are crucial for identifying rare or delayed adverse drug reactions.
  • Increased awareness among patients and healthcare providers regarding potential long-term side effects of commonly used medications like sitagliptin is essential.
  • This case emphasizes the need for vigilant patient safety protocols and personalized treatment adjustments in diabetes care.