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Updated: Feb 8, 2026

Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
Autochthonous acute hepatitis E: treatment with sofosbuvir and ribavirin
Elisa Biliotti1, Cristiana Franchi2, Martina Spaziante2
1Department of Clinical Medicine, Clinic of Tropical Medicine, Sapienza University of Rome, Rome, Italy. elisabiliotti@yahoo.it.
Introduction:
Hepatitis E virus (HEV) is an emerging cause of autochthonous-acute-hepatitis and acute-on-chronic-liver-failure in western countries. Treatment is not routinely used, despite ribavirin has a good antiviral effect. In vitro sofosbuvir inhibits HEV replication, but clinical data are lacking.
Case Report:
We report a case of acute-on-chronic-liver-failure due to HEV treated with sofosbuvir and ribavirin. The treatment was capable of rapidly inducing both HCV and HEV viral suppression.
Conclusion:
In conclusion, although more data are required before firm conclusions could be drawn, the combination of sofosbuvir and ribavirin in not immunosuppressed patients with acute hepatitis E may be able to clear HEV infection.
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