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Updated: Feb 8, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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Published on: November 12, 2012

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Enzymatic Thioamide Formation in a Bacterial Antimetabolite Pathway

Agnieszka Litomska1, Keishi Ishida1, Kyle L Dunbar1

  • 1Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Chemistry and Infection Biology (HKI), Beutenbergstr. 11a, 07745, Jena, Germany.

Angewandte Chemie (International Ed. in English)
|June 28, 2018
PubMed
Summary

Researchers discovered a unique enzyme system in plant pathogens that creates 6-thioguanine (6TG), a cancer drug and bacterial toxin. This finding reveals novel mechanisms for forming carbon-sulfur bonds in nature.

Keywords:
biosynthesisenzymesnatural productnucleic acidsthioamides

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