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The impact of TFPI on coronary atherosclerotic burden

S Kahraman, R Erdim, F Helvacioglu

    Bratislavske Lekarske Listy
    |June 28, 2018
    PubMed

    Insights

    Endothelial dysfunction (ED), increased carotid intima-media thickness (CIMT), and Tissue Factor Pathway Inhibitor (TFPI) levels are associated with coronary artery disease (CAD). Higher CIMT and lower FMD/NMD correlate with CAD severity.

    Area of Science:

    • Cardiovascular Medicine
    • Vascular Biology
    • Biomarkers of Atherosclerosis

    Background:

    • Endothelial dysfunction (ED) plays a key role in atherosclerosis development.
    • Carotid intima-media thickness (CIMT) and Tissue Factor Pathway Inhibitor (TFPI) activity are established markers associated with atherosclerosis and coronary artery disease (CAD).

    Purpose of the Study:

    • To investigate the association between the presence and severity of coronary artery disease (CAD).
    • To evaluate the relationship between CAD and endothelial dysfunction (ED), carotid intima-media thickness (CIMT), and Tissue Factor Pathway Inhibitor (TFPI) levels.

    Main Methods:

    • Prospective observational study involving 50 patients with CAD and 30 controls with normal coronary arteries.
    • Endothelial function assessed via flow-mediated dilatation (FMD) and nitroglycerine-mediated dilatation (NMD).
    • Measurements included CIMT and serum TFPI levels.

    Main Results:

    • Elevated TFPI levels were significantly higher in patients with CAD (84.9 ± 19.3 vs 70.2 ± 14.7, p = 0.001).
    • A positive correlation was found between CIMT and Gensini score (r = 0.34, p = 0.014).
    • Strong negative correlations observed between Gensini score and FMD/NMD (FMD: r = -0.715, p < 0.001; NMD: r = -0.718, p < 0.001).

    Conclusions:

    • Endothelial dysfunction (ED), elevated CIMT, and increased TFPI levels are significantly associated with the presence of CAD.
    • Increased CIMT and decreased FMD/NMD values demonstrate a positive correlation with coronary artery disease severity (Gensini score).
    Abstract

    Keywords:
    coronary artery diseaseendothelial dysfunction tissue factor pathway inhibitor.

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