A Multifunctional Metal-Organic Framework for Oxidative C-O Coupling Involving Direct C-H Activation and Synthesis of Quinolines
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Updated: Feb 8, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
Vivekanand Sharma1, Dinesh De1, Parimal K Bharadwaj1
1Department of Chemistry , Indian Institute of Technology Kanpur , Kanpur 208016 , Uttar Pradesh , India.
Abstract:
A robust paddle-wheel Cu(II)-based metal-organic framework (MOF) 1, having dual functionalities, namely, Lewis acid and basic sites, has been explored as a heterogeneous catalyst. This MOF, because of its large void volume (10298 Å3, 67.6%), large surface area (1480 m2/g), and high thermal stability, encouraged us to see its applicability in two catalytic reactions, namely, oxidative C-O coupling (cross-dehydrogentaive coupling reaction) involving direct C-H activation and Friedländer reaction under solvent free and ambient conditions. This study demonstrates the green aspect of MOFs in coupling reactions because of the simplified recovery, shorter reaction time, minimum waste, and smooth activation of the C-H bond, which is very challenging in synthetic chemistry.
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