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Updated: Feb 8, 2026

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Primary umbilical endometriosis
Paulo Vicente Dos Santos Filho1, Marcelo Protásio Dos Santos1, Samanta Castro1
1Department of General Surgery, Charitable Foundation Surgery Hospital (FBHC), Aracaju, SE, Brazil.
Primary umbilical endometriosis, a rare condition, presents as painful, bleeding umbilical nodules. Complete surgical removal is the recommended treatment for this uncommon diagnosis.
Area of Science:
- Gynecology
- Surgical Pathology
Background:
- Endometriosis is a condition where tissue similar to the uterine lining grows outside the uterus.
- Primary umbilical endometriosis is a rare manifestation, presenting as a distinct nodule at the navel.
Purpose of the Study:
- To characterize the clinical presentation, diagnostic methods, treatment, and outcomes of patients with primary umbilical endometriosis.
- To highlight the importance of considering umbilical endometriosis in the differential diagnosis of umbilical nodules.
Main Methods:
- An observational, descriptive study was conducted.
- Data from six patients diagnosed between 2014 and 2017 were analyzed.
- Clinical variables included age, symptoms, lesion characteristics, diagnosis, treatment, and recurrence.
Main Results:
- Six patients aged 28-45 years with umbilical endometriosis were treated.
- Lesions varied from 1-2.5 cm, with characteristic violet or erythematous-violaceous appearance.
- Diagnosis was confirmed via histopathology after clinical suspicion, with symptoms lasting 1-3 years.
- All patients experienced cyclical umbilical pain and bleeding; no associated neoplasms were found.
Conclusions:
- Umbilical endometriosis is an uncommon condition that should be considered in the differential diagnosis of women presenting with umbilical nodules.
- The primary treatment involves complete surgical excision of the affected tissue.
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