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PREVALENCE AND RISK FACTORS OF HYPERKALEMIA AFTER LIVER TRANSPLANTATION

Helem Sena Ribeiro1, Michelle Carvalho Oliveira2, Lucilene Rezende Anastácio3

  • 1Postgraduate Program in Applied Sciences for Surgery, Faculty of Medicine.

Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery
|June 28, 2018
PubMed

Insights

Hyperkalemia, or high potassium levels, affects less than 20% of liver transplant recipients one month post-surgery, decreasing over time. Individualized treatment is recommended for these patients.

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Internal Medicine

Background:

  • Limited data exists on hyperkalemia incidence and risk factors following liver transplantation.
  • Hyperkalemia poses a significant post-transplant complication risk.

Purpose of the Study:

  • To determine the prevalence of hyperkalemia in liver transplant recipients.
  • To identify factors associated with hyperkalemia post-liver transplant.

Main Methods:

  • Retrospective cohort study of 147 liver transplant patients with one year of follow-up.
  • Data collected included demographics, serum electrolytes (potassium, sodium), renal function (urea, creatinine), and medications.
  • Hyperkalemia defined as serum potassium > 5.5 mEq/l.

Main Results:

  • Hyperkalemia prevalence was 18.4% at 1 month, 17.0% at 6 months, and 6.1% at 12 months post-transplant.
  • Associated factors included older age, low creatinine clearance, elevated urea, hypernatremia, and prednisone dosage at six months.
  • Significant p-values (p<0.05) were observed for all identified risk factors.

Conclusions:

  • Hyperkalemia is a common, yet decreasing, complication in the first year after liver transplantation.
  • Risk factors such as age and renal function warrant monitoring.
  • Individualized potassium management is crucial, avoiding universal recommendations.
Abstract

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