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Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Novel approaches to restore beta cell function in prediabetes and type 2 diabetes
Vishal A Salunkhe1, Rajakrishnan Veluthakal1, Steven E Kahn2
1Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.
Diabetologia
|June 28, 2018
Summary
Type 2 diabetes is rising globally. New research explores innovative strategies targeting beta cells, insulin sensitivity, and even the brain to combat prediabetes and diabetes progression.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Diabetes Research
Background:
- Global prevalence of diabetes mellitus has surged, with type 2 diabetes comprising over 90% of cases.
- Prediabetes affects over 40% in some regions, linked to rising obesity rates.
- Urgent need for novel strategies to prevent prediabetes and type 2 diabetes progression.
Purpose of the Study:
- Review advancements in improving beta cell function and insulin sensitivity.
- Explore novel therapeutic candidates with multitasking potential.
- Highlight emerging targets for glucose regulation.
Main Methods:
- Literature review of research over the past decade.
- Analysis of strategies enhancing insulin secretion and sensitivity.
- Examination of multitasking therapeutic candidates.
Main Results:
- Significant progress in enhancing beta cell function and insulin sensitivity.
- Identification of multitasking agents impacting both beta cell and peripheral tissues.
- Emerging evidence for the brain as a critical glucose regulatory target.
Conclusions:
- Multi-faceted approaches show promise for type 2 diabetes management.
- Targeting multiple tissues offers a comprehensive strategy.
- Understanding type 2 diabetes pathogenesis requires a multi-tissue perspective.
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