Related Experiment Video
Updated: Feb 8, 2026

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
Published on: November 5, 2012
Chromatin mobility upon DNA damage: state of the art and remaining questions
Christophe Zimmer1,2, Emmanuelle Fabre3,4
1Unité Imagerie et Modélisation, Institut Pasteur, 25 rue du Docteur Roux, 75015, Paris, France. christophe.zimmer@pasteur.fr.
Abstract:
Chromosome organization and chromatin mobility are central to DNA metabolism. In particular, it has been recently shown by several labs that double strand breaks (DSBs) in yeast induce a change in chromatin mobility at the site of the damage. Intriguingly, DSB also induces a global mobility of the genome, at others, potentially undamaged positions. How mobility is regulated and what are the functional outcomes of these global changes in chromatin dynamics are, however, not yet fully understood. We present the current state of knowledge in light of the recent literature and discuss some perspectives opened by these discoveries towards genome stability.
Related Concept Videos
Chromatin Packaging
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
Chromatin Packaging
Chromatin Packaging
DNA Damage Can Stall the Cell Cycle
DNA Damage can Stall the Cell Cycle
Inheritance of Chromatin Structures

