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Related Experiment Video

Updated: Feb 8, 2026

An Orthotopic Model of Murine Bladder Cancer
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Modeling human bladder cancer.

Cassandra Ringuette-Goulet1,2,3, Stéphane Bolduc1,2, Frédéric Pouliot4,5

  • 1Centre de recherche en organogénèse expérimentale/LOEX, Regenerative Medicine Division, CHU de Québec Research Center, Quebec, QC, Canada.

World Journal of Urology
|June 28, 2018
PubMed
Summary

Developing better bladder cancer models is crucial for advancing treatment. Current in vitro and in vivo models have limitations, but 3D cultures show promise for recapitulating tumor complexity and improving therapy translation.

Keywords:
3D modelsAnimal modelsBladder cancer

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Area of Science:

  • Oncology
  • Translational Research
  • Biomedical Engineering

Background:

  • Bladder cancer poses a significant public health challenge.
  • Existing treatments struggle to prevent cancer recurrence and progression.
  • Effective experimental models are needed to study bladder cancer pathology.

Purpose of the Study:

  • To review and compare available in vitro and in vivo bladder cancer models.
  • To identify the advantages and limitations of current experimental models.
  • To guide the selection of appropriate models for bladder cancer research.

Main Methods:

  • A systematic PubMed search was conducted.
  • Keywords included "bladder cancer" and "models".
  • The search was executed in March 2017.

Main Results:

  • Currently available in vitro (2D and 3D) and in vivo rodent models were reviewed.
  • Despite various animal models, reliable and reproducible ones remain challenging.
  • Advanced 3D culture systems better mimic tumor heterogeneity and microenvironment.

Conclusions:

  • Understanding model limitations and advantages is key.
  • Selecting the most appropriate model enhances therapy development.
  • Appropriate models facilitate the translation of laboratory findings to clinical practice.