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Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.7K

New emerging roles of microRNAs in breast cancer

Edna Ayerim Mandujano-Tinoco1,2, Alfredo García-Venzor1, Jorge Melendez-Zajgla3

  • 1Epigenetics Laboratory, Instituto Nacional de Medicina Genómica, Periferico Sur 4809, Arenal Tepepan, 14610, Mexico, CDMX, Mexico.

Breast Cancer Research and Treatment
|June 28, 2018
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer development. Understanding their role in tumorigenesis can improve breast cancer diagnosis and treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs involved in regulating mRNA targets.
  • Altered miRNA expression is implicated in various breast cancer processes.
  • Breast cancer is a prevalent global health concern for women.

Purpose of the Study:

  • To review the role of miRNAs as master regulators in breast tumorigenesis.
  • To highlight the significance of miRNAs in breast cancer pathology.

Main Methods:

  • An integrative literature review of miRNAs and breast cancer was conducted using PubMed.
  • Focused on research from the past 5 years.
  • Summarized studies on miRNA biogenesis defects, cellular processes, and clinical applications.

Main Results:

  • Defects in miRNA biogenesis correlate with distinct breast cancer characteristics.
  • miRNAs regulate key cellular processes linked to breast cancer hallmarks.
  • miRNAs are modulated by other non-coding RNAs, adding regulatory complexity.

Conclusions:

  • miRNAs show potential as diagnostic and classification tools for breast cancer.
  • Further research into miRNAs can enhance diagnostic and therapeutic strategies for breast cancer.
Keywords:
Breast cancerCancerStem cellsmiRNA

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