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GFR-estimation by serum creatinine during glucocorticosteroid therapy.
Emil den Bakker1, Berend Koene2, Joanna A E van Wijk2
1Department of Pediatric Nephrology, VU University Medical Center, De Boelelaan 1112, 1081 HV, Amsterdam, The Netherlands. e.denbakker@outlook.com.
Clinical and Experimental Nephrology
|June 28, 2018
Summary
Glucocorticosteroids (GCS) do not significantly impact serum creatinine levels in children with kidney disease. This study found no significant effect of GCS on kidney function markers.
Area of Science:
- Pediatric Nephrology
- Pharmacology
- Clinical Chemistry
Background:
- Glucocorticosteroids (GCS) are frequently prescribed for pediatric kidney diseases.
- The impact of GCS on serum creatinine, a key indicator of kidney function, remains unclear.
- Understanding this relationship is crucial for accurate patient monitoring.
Purpose of the Study:
- To investigate the effect of glucocorticosteroids (GCS) on serum creatinine levels in children with kidney disease.
- To evaluate GCS influence on the accuracy of estimated glomerular filtration rate (eGFR) compared to measured GFR (Cin).
Main Methods:
- A paired analysis compared eGFR and Cin in 22 children on and off GCS treatment.
- A cross-sectional study analyzed 42 children receiving GCS, exploring dose-dependent effects.
- Serum creatinine was the primary dependent variable in regression analyses.
Main Results:
- The paired analysis revealed no significant difference in the discrepancy between eGFR and Cin (ΔGFR) with or without GCS.
- Multivariate regression analysis indicated age correlated with measured GFR (Cin).
- Glucocorticosteroid dosage did not show a significant relationship with serum creatinine levels.
Conclusions:
- Glucocorticosteroid (GCS) use does not significantly alter serum creatinine levels in pediatric patients with kidney disease.
- Serum creatinine remains a reliable marker for kidney function assessment in children treated with GCS.
- Further research may explore other potential GCS effects on renal parameters.
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