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Ipilimumab treatment associated with myasthenic crises and unfavorable disease course

Eda Derle1, Sibel Benli2

  • 1Department of Neurology, Baskent University Faculty of Medicine, Mareşal Fevzi Çakmak Cad 10.sok No: 45 Bahçelievler, Ankara, Turkey. edaderle@hotmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|June 28, 2018
PubMed

Ipilimumab, a monoclonal antibody targeting the cytotoxic T lymphocyte antigen-4 is a treatment option for metastatic melanoma. This receptor serves as an inhibitor receptor on T lymphocytes and blockage of these results predisposition to autoimmune diseases. The patients with autoimmune disorders were excluded in clinical trials and there is no sufficient data of the treatment on these patients who already have an autoimmune disorder. Here, we report a case of myasthenia gravis who was treated with ipilimumab and we presented the long-term prognosis of the patient after treatment.

Keywords:
Autoimmune diseaseCTLA-4Immune check point inhibitorImmune related adverse eventsIpilimumabMyasthenia gravis

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