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The Histone Acetylation Modifications of Breast Cancer and their Therapeutic Implications

Pingping Guo1, Wenqi Chen1, Huiyu Li1

  • 1The Key Laboratory of Pathobiology, Ministry of Education, Norman Bethune Medical College, Jilin University, Changchun, 130021, China.

Pathology Oncology Research : POR
|June 28, 2018
PubMed

The histone acetylation modifications (HAMs) influence a large number of cellular functions. They are mediated through histone acetyltransferase (HAT) and histone deacetylase (HDAC). Nowadays, people have realized that HAMs are crucial for development and prognosis of breast cancer. Investigations about abnormal HAMs in breast cancer focus on initiating molecular mechanisms in breast cancer development, identification of new biomarkers to predict breast cancer aggressiveness and the therapeutic potential. As HAMs are reversible, breast cancer may be treated by restoring HAMs to normal levels. Indeed, some HDAC inhibitors have been approved by the US Food and Drug Administration to treat certain cancers. Furthermore, HAT inhibitors, HAT activators and HDAC activators may also be used as drugs to treat breast cancer.

Keywords:
Breast cancerHistone acetylationHistone deacetylationTherapy

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