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Perturbed Developmental Serotonin Signaling Affects Prefrontal Catecholaminergic Innervation and Cortical Integrity
Lidiane P Garcia1, Josefine S Witteveen1, Anthonieke Middelman2
1Donders Institute for Brain, Cognition, and Behaviour, Centre for Neuroscience, Department of Molecular Animal Physiology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen, Geert Grooteplein Zuid 28, 6525 GA, Nijmegen, The Netherlands.
Molecular Neurobiology
|June 28, 2018
Summary
The study reveals that the serotonin transporter (5-HTT) is crucial for the parallel development of serotonergic and catecholaminergic systems in the medial prefrontal cortex (mPFC). Its absence impacts mPFC neuron development and interneuron integration.
Area of Science:
- Neuroscience
- Developmental Biology
- Neurobiology
Background:
- The medial prefrontal cortex (mPFC) is vital for cognitive functions.
- Its development relies on serotonergic (5-HT) and catecholaminergic systems.
- The interaction between these systems during development is not well understood.
Purpose of the Study:
- To investigate the parallel development of 5-HT and catecholaminergic systems in the rat mPFC.
- To elucidate the role of the 5-HT transporter (5-HTT) in this developmental process.
- To examine the impact of 5-HTT absence on mPFC neuronal development and interneuron integration.
Main Methods:
- Comparative analysis of 5-HT and catecholaminergic projections in developing rats.
- Investigation of mPFC development in the absence of the 5-HTT.
- Assessment of neuronal layer identity and reelin-positive interneuron characteristics.
Main Results:
- Demonstrated parallel development and close proximity of 5-HT and catecholaminergic systems near Cajal-Retzius cells.
- Showed that absence of 5-HTT affects both 5-HT and catecholaminergic systems' projections to the mPFC.
- Observed alterations in mPFC neuronal layer identity and reelin-positive interneuron number and integration in 5-HTT deficient rats.
Conclusions:
- Established a functional interplay between developing 5-HT and catecholaminergic systems in the mPFC.
- Highlighted the significant impact of 5-HTT on the development of both neurotransmitter systems and mPFC structure.
- Advocated for a holistic approach to understand neurotransmitter system development for improved neuropsychiatric disorder treatments.
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