Related Experiment Video

Updated: Feb 8, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.6K

Two-Stage Revision Arthroplasty for the Treatment of Prosthetic Joint Infection

Ryan S Charette1, Christopher M Melnic2

  • 1Resident, Orthopaedic Surgery, University of Pennsylvania, 3737 Market Street, 6th Floor, Philadelphia, PA, 19104, USA. ryan.charette@uphs.upenn.edu.

Current Reviews in Musculoskeletal Medicine
|June 28, 2018
PubMed
Abstract

Insights

Two-stage revision arthroplasty effectively treats prosthetic joint infection (PJI). Both mobile and static antibiotic spacers show similar infection eradication rates, with mobile spacers improving joint range of motion.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Prosthetic joint infection (PJI) is a significant complication following arthroplasty.
  • Effective management of PJI is crucial for patient outcomes and implant survival.
  • Two-stage revision arthroplasty is a primary surgical approach for PJI treatment.

Purpose of the Study:

  • To review the diagnosis and treatment of PJI.
  • To focus on the efficacy of two-stage revision arthroplasty.
  • To compare different antibiotic spacer constructs in total knee and total hip arthroplasty.

Main Methods:

  • Review of current literature on PJI diagnosis and treatment.
  • Analysis of clinical outcomes for various antibiotic spacer types (mobile vs. static).
  • Focus on two-stage revision arthroplasty protocols and outcomes.

Main Results:

  • No significant difference in infection eradication between mobile and static antibiotic spacers.
  • Mobile spacers demonstrated improved knee range of motion post-revision.
  • Two-stage revision arthroplasty, utilizing antibiotic spacers, is the gold standard for PJI.

Conclusions:

  • Mobile and static antibiotic spacers are equally effective in eradicating PJI.
  • Mobile spacers offer functional benefits, such as improved joint mobility, between surgical stages.
  • Two-stage revision arthroplasty remains the definitive treatment for PJI, with antibiotic spacers playing a key role.
Keywords:
Antibiotic spacerProsthetic joint infectionTotal hip arthroplastyTotal knee arthroplastyTwo-stage revision

More Related Videos

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

3.9K
Customizing a Cryolite Glass Prosthetic Eye08:04

Customizing a Cryolite Glass Prosthetic Eye

Published on: October 31, 2019

11.3K

Related Concept Videos

Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.4K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
7.1K
Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.8K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
4.1K
Joints01:26

Joints

Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.8K
Method of Joints01:30

Method of Joints

The method of joints is a commonly used technique to analyze the forces in structural trusses. The method is based on the principle of equilibrium, which assumes that the truss members are connected by frictionless pins. The forces at each joint can be determined by considering the equilibrium of the forces acting on that joint.
Since plane truss members are in the same plane, each joint is subjected to a coplanar and concurrent force system. To apply the method of joints, the first step is to...
1.3K