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Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method
Veronika Pechová1, Jan Gajdziok2, Jan Muselík1
1Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1, 612 42, Brno, Czech Republic.
AAPS Pharmscitech
|June 28, 2018
Summary
This study developed benzydamine hydrochloride orodispersible films using a modified solvent casting method. Lower dextrose equivalent maltodextrins and xylitol plasticization resulted in films with improved mechanical properties and faster disintegration.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Orodispersible films offer a convenient alternative for drug delivery, particularly for patients with swallowing difficulties.
- Developing efficient and scalable methods for producing these films is crucial for pharmaceutical applications.
Purpose of the Study:
- To develop benzydamine hydrochloride-loaded orodispersible films using a modified solvent casting technique.
- To investigate the impact of film-forming maltodextrins, plasticizers, and superdisintegrants on film properties and performance.
Main Methods:
- A modified solvent casting method was employed, utilizing a heated inert base for film drying.
- Two types of film-forming maltodextrins with varying dextrose equivalent values and two polyol plasticizers (xylitol, sorbitol) were evaluated.
- The effect of superdisintegrant Kollidon® CL-F on disintegration time was assessed.
Main Results:
- Films formulated with lower dextrose equivalent maltodextrins exhibited superior mechanical properties, lower moisture content, and reduced disintegration times.
- Xylitol-plasticized films demonstrated faster disintegration compared to sorbitol-plasticized films.
- The addition of Kollidon® CL-F did not significantly alter the disintegration time.
Conclusions:
- The modified solvent casting method is a promising technique for small-scale laboratory production of orodispersible films.
- Formulation parameters, particularly maltodextrin type and plasticizer choice, significantly influence the characteristics of benzydamine hydrochloride orodispersible films.
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