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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

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Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
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Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

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Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
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Related Experiment Video

Updated: Feb 8, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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PET/CT of Dementia.

Katherine Zukotynski1,2,3, Phillip H Kuo4, David Mikulis5

  • 11 Department of Medicine, McMaster University, 1200 Main St W, Rm 1P11, Hamilton, ON L8N 3Z5. Canada.

AJR. American Journal of Roentgenology
|June 28, 2018
PubMed
Summary

Positron Emission Tomography/Computed Tomography (PET/CT) offers advanced insights into dementia management beyond standard imaging. This functional imaging technique aids in differentiating dementia types and guiding treatment strategies.

Keywords:
PET/CTamyloiddementiaimagingtau

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Area of Science:

  • Neurology
  • Radiology
  • Nuclear Medicine

Background:

  • Standard dementia diagnostics rely on CT and MRI for structural assessment, including lesion detection and atrophy measurement.
  • These modalities are crucial for excluding other neurological conditions and monitoring disease progression.
  • Limitations exist in differentiating specific dementia subtypes using conventional imaging alone.

Purpose of the Study:

  • To review the current literature on the role of PET/CT in dementia management.
  • To present evidence-based best clinical practices for utilizing PET/CT in dementia diagnosis and care.
  • To discuss recent technological and methodological advancements in PET/CT for neurological disorders.

Main Methods:

  • Systematic review of published literature on PET/CT applications in dementia.
  • Analysis of clinical evidence supporting the use of PET/CT in differentiating dementia subtypes.
  • Discussion of emerging PET/CT radiotracers targeting specific neuropathological markers.

Main Results:

  • PET/CT provides functional information, particularly through Fluorine-18-FDG PET/CT, by mapping brain glucose metabolism.
  • This functional data complements structural imaging, aiding in the differential diagnosis of various dementia types.
  • Newer PET tracers enable visualization of key pathologies such as amyloid plaques, tau tangles, and neuroinflammation.

Conclusions:

  • PET/CT is a valuable tool that significantly influences dementia management by providing etiological insights.
  • Its ability to differentiate dementia types and visualize specific biomarkers enhances diagnostic accuracy and treatment planning.
  • Continued advancements in PET/CT technology promise further improvements in the clinical care of dementia patients.