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Updated: Feb 8, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
Published on: August 2, 2015
Highly Efficient Cell-Penetrating Probes of Protein Arginine Deiminases for Functional Proteomics
Sanjai Kumar1,2
1Department of Chemistry and Biochemistry, Queens College-CUNY, 65-30 Kissena Blvd., Queens, NY, 11367, USA.
Abstract:
Protein arginine deiminases (PADs) have recently emerged at the forefront of drug-discovery programs for several human disorders. Despite this, a precise understanding of their functional roles in human biology remains to be fully elucidated. This report highlights a recent development of next-generation activity-based PAD probes that are highly efficient, cell active, and metabolically stable. This discovery should rapidly expedite functional assignments of PAD biology in both normal and diseased cells, thereby leading to the development of PAD-targeted therapeutics in the near future.
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