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LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b
Jin Ren1, Jinling Fu2, Tiangang Ma1
1a Department of Respiratory medicine , the Second Hospital of Jilin University , Changchun , P.R. China.
Cell Cycle (Georgetown, Tex.)
|June 29, 2018
Summary
Long non-coding RNA H19 accelerates lung cancer by increasing LIN28B expression. H19 sponges miR-196b, leading to elevated LIN28B and promoting tumor cell proliferation.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Long non-coding RNA H19 (H19) is implicated in various cancer developments.
- LIN28B, an RNA binding protein, plays a role in cancer progression.
Purpose of the Study:
- To investigate the role of H19 in lung cancer growth.
- To elucidate the mechanism by which H19 influences LIN28B and miR-196b in lung cancer.
Main Methods:
- Analysis of H19 and LIN28B expression in clinical lung cancer samples.
- In vitro studies using lung cancer cells to assess the interaction between H19, LIN28B, and miR-196b.
- Functional assays to determine the impact of H19-LIN28B axis on cell proliferation.
Main Results:
- H19 expression is positively correlated with LIN28B abundance in clinical lung cancer tissues.
- H19 directly sponges miR-196b, thereby relieving the inhibition of miR-196b on LIN28B.
- Elevated LIN28B due to H19 promotes lung cancer cell proliferation.
Conclusions:
- H19 promotes lung cancer progression by upregulating LIN28B through sequestering miR-196b.
- The H19/miR-196b/LIN28B axis represents a potential therapeutic target for lung cancer.
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